Health Condition 1: null- Infants age less than 6 months suffering from bacterial infections
Conditions
Interventions
Intervention1: Intramuscular Gentamicin: Infants found suitable as per inclusion criteria were administered intramuscular gentamicin (5mg/kg). Blood samples (2ml) were taken from each patient to deter
Sponsors
Lady Hardinge Medical College
Eligibility
Inclusion criteria
Inclusion criteria: All infants of age less than or equal to 6 months admitted to a Paediatric unit of Kalawati Saran Children Hospital, New Delhi with suspected or confirmed infections considered suitable for gentamicin therapy such as, i. Suspected Gram-negative sepsis, ii. Infections like acute enteritis, pneumonia, meningitis and septic arthritis, and iii. Urinary tract infection (UTI)
Exclusion criteria
Exclusion criteria: i. Age greator than 6 months ii. Abnormal renal functions (serum urea and creatinine). iii. Earlier diagnosed cases of impaired internal ear function or deafness. iv. Severely ill patients or those with life-threatening infections.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Peak and Trough serum gentamicin concentrations (SGCs) post single dose of intravenous gentamicin and intramuscular gentamicin injections.Timepoint: After 30 minutes and 60 minutes of IV and IM administration of gentamicin respectively, to determine serum peak levels of gentamicin. To estimate trough serum gentamicin levels after 18 hours of administration of gentamicin by either route. | — |
Secondary
| Measure | Time frame |
|---|---|
| No secondary OutcomesTimepoint: Not Applicable | — |
Countries
India
Contacts
Public ContactDr Sumit Kumar Kulhare
Lady Hardinge Medical College, New Delhi
Outcome results
None listed