Skip to content

A clinical trial to study which of the two methods of giving etomidate (drug used to induce anaesthesia) i)Etomidate given slowly ii)Etomidate given after injecting a very small dose of itself, results in lesser occurrence of side effect myoclonus (shivering movement)

Etomidate induced myoclonus: A comparison of priming vs slow injection - RCT

Status
Recruiting
Phases
Phase 4
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2015/02/005592
Enrollment
189
Registered
2015-02-27
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Patients requiring elective surgery under general anaesthesia

Interventions

Intervention1: Etomidate induction dose is given over 20 seconds after priming dose
etomidate induction dose is given in 2 minutes with no priming dose. : Patients in Priming group (Group P) will receive a priming dose of intravenous 0.03 mg/kg etomidate followed one minute later by

Sponsors

VMMC and Safdarjang Hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: age group 18 to 60 years Of either gender ASA physical status I â?? II Scheduled for elective surgery under general anaesthesia of less than three hours duration.

Exclusion criteria

Exclusion criteria: Patients with co-existing moderate to severe systemic illness Pre-existing adrenal disease or adrenocortical insufficiency Patients on steroid medication or those who have received steroids in last three months Sepsis Hypersensitivity to study drug History of seizure disorder or neurological disease.

Design outcomes

Primary

MeasureTime frame
MyoclonusTimepoint: 3 minutes from start of injection of induction dose of etomidate

Secondary

MeasureTime frame
Haemodynamic parametersTimepoint: From start of induction till 5 minutes following endotracheal intubation.

Countries

India

Contacts

Public ContactDr Parul Mullick

Vardhman Mahavir Medical College and Safdarjang Hospital

parash93@yahoo.com9810606262

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026