Health Condition 1: null- Coronary Artery Disease
Conditions
Interventions
Intervention1: Dronedarone: Class III antiarrhythmic
1 tablet (400mg) two times daily orally for 3 days pre-operatively till the morning of surgery and patient monitored till 24 hours post-opeartively
Control Intervention1: Amiodarone: Class III antiarr
amiodarone 3 mg/kg intravenously given as a single dose intra-operatively and patient monitored till 24 hours post-opeartively
Sponsors
IPGMER Kolkata
IPGMER Kolkata
Eligibility
Inclusion criteria
Inclusion criteria: Modified Parsonnet score: between 0 and 10; Patients scheduled for off-pump coronary artery bypass grafting
Exclusion criteria
Exclusion criteria: Female patients; Modified Parsonnet score 10.5 and more; Any contraindication or history of allergy to any of the two drugs under study; Co-morbid conditions like asthma, COPD, diabetes mellitus, chronic renal disease requiring haemodialysis; Ejection fraction less than 30%; Left main coronary artery disease; Left ventricular aneurysm; Permanent pacing; Prior valve surgery; Morbid obesity; Peripheral arterial disease; Prolonged corticosteroid use.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| maximum ventricular rate during atrial fibrillationTimepoint: intra-operative and first 24 hours post-operative period | — |
Primary
| Measure | Time frame |
|---|---|
| incidence of arrhythmiasTimepoint: intra-operative and first 24 hours post-operative period | — |
Countries
India
Contacts
Public ContactDr Anirban Som
IPGMER Kolkata
Outcome results
None listed