A clinical study on effect of formulation of Calotropis and turmeric in the management of freckles and melasma i.e darkening of facial skin.

A study on collection and shodhana of Arka (Calotropis procera) and Shweta arka (Calotropis gigantea) kshira (latex) with special reference to their clinical efficacy on mukhakarshnya

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2015/02/005504

Enrollment

Registered

2015-02-06

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Mukhakarshnya(hyperpigmentation disorders like freckles, melasma, etc.)

Interventions

Intervention1: Gel preparation for external application: Gel made up of oil of Calotropis procera latex and turmeric powder. Intervention2: one arm receives CP gel made and other receives CG gel: CP g

Eligibility

Inclusion criteria

Inclusion criteria: Patients irrespective of age and sex with clinically significant symptoms of mukha karshnya. Patients having chronic exposure to sun who have developed freckles.

Exclusion criteria

Exclusion criteria: Patients with recent history of C.A. Patients with history of allergic or hypersensitive reaction to any ingredients of the regimen

Design outcomes

Primary

Measure	Time frame
Primary expected outcome will be decrease in number of freckles and size of melasma patches and decrease in darkness of the hyperpigmented skin.Timepoint: 1 year	—

Secondary

Measure	Time frame
development of calotropis procera and gigantea formulation in management of hyperpigmentation.Timepoint: 1 year	—

Countries

India

Contacts

Public ContactRabinarayan Acharya

IPGT and RA GAU Jamnagar

drrnacharya@gmail.com

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026