to compare dexmedetomidine and propofol for sedation during simple operative procedures.

A comparative study of dexmedetomidine and propofol for sedation during endoscopic retrograde cholangiopancreatography(ERCP) in patients with impaired liver functionâ??

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2015/01/005465

Enrollment

Registered

2015-01-27

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- patients with impaired liver function

Interventions

Intervention1: dexmedetomidine: to compare the sedative efficacy of dexmedetomidine and propofol in ERCP patients. A loading dose of 1mcg /kg will be given over 10 mins then infusion will be started

Eligibility

Inclusion criteria

Inclusion criteria: • Patients undergoing elective ERCP with impaired liver function (i.e. raised serum bilirubin ,SGOT or SGPT levels) • Normal prothrombin time (PT) and international normalized ratio (INR) • ASA grade II. • Aged between 18 and 60 years. • Those who are willing to give written informed consent

Exclusion criteria

Exclusion criteria: • ASA grade III or more. • Patients with comorbid conditions such as HTN, DM or renal insufficiency. • Patients having difficulty in communication (due to language problem or deafness). • Patients with history of operative intervention in the past 72 hrs. • Patients with the known allergy to these drugs and with a history of sulphite ,egg or soyabean allergy • Pregnant patients.

Design outcomes

Primary

Measure	Time frame
to compare dexmedetomidine and propofol for sedative efficacy in patients with impaired liver functionTimepoint: To assess the recovery from sedation at 5 mins,10 mins, and 15 mins after procedure	—

Secondary

Measure	Time frame
to compare the sedative efficacy as well as complications of both the drugsTimepoint: 1 year	—

Countries

India

Contacts

Public ContactDR NIDA NAWAZ

MD Anaesthesia & intensive care, PGI Chandigarh

deepakswat@yahoo.com08578042725

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026