Health Condition 1: null- Cirrhosis with Minimal Hepatic encephalopathy
Conditions
Interventions
Intervention1: Lactulose: Lactulose therapy will be given to 50 patients of cirrhosis with MHE for 3 months. Starting at a dose of 30ml 6 hourly and will be titrated accordingly to have a stool freque
Sponsors
GB Pant Hospital
Eligibility
Inclusion criteria
Inclusion criteria: Patients of Cirrhosis with and without MHE
Exclusion criteria
Exclusion criteria: -Overt HE or history of overt HE - History of shunt surgery or transjuglar intrahepatic portosystemic shunt for portal hypertension -Electrolyte imbalance (Na 150meq and K 5.5meq) at the time of evaluation - Evidence of Infection ( Fever,TLC >11000) at the time of enrolment -History of recent use (within one month) of drugs affecting psychometric performances like benzodiazepines, antiepileptics, or psychotropic drugs - Hepatocellular carcinoma - Severe medical problems such as congestive heart failure, pulmonary disease, or neurological or psychiatric disorder that could influence quality-of-life measurement; and inability to perform neuropsychological tests . - History of alcohol intake within last one month. - History of intake of lactulose,rifaximin, L-ornithine-L-aspartate or probiotics in last one month. - History of GI bleed in last one month, spontaneous bacterial peritonitis (SBP) on prophylaxis or hepatorenal syndrome (HRS). - Patients of acute on chronic liver failure (ACLF).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| -Improvement in quality of sleep -Improvement or worsening in MHE. -Improvement in health related quality of life. Timepoint: -Improvement in quality of sleep -Improvement or worsening in MHE. -Improvement in health related quality of life. | — |
Secondary
| Measure | Time frame |
|---|---|
| --Changes in CTP and MELD score. -Hospital admission -Mortality Timepoint: 3 months | — |
Countries
India
Contacts
Public ContactDr BC Sharma
Delhi University
Outcome results
None listed