Health Condition 1: null- Cirrhosis with and without minimal Hepatic encephalopathy
Conditions
Interventions
Intervention1: Lactulose: 30 ml lactulose will be given orally three times a day and titrated to have 2-3 semisolid stools per day, for 3 months
Control Intervention1: Nil: Nil
Sponsors
GB Pant Hospital
Eligibility
Inclusion criteria
Inclusion criteria: Patients of Cirrhosis with and without MHE
Exclusion criteria
Exclusion criteria: -Overt HE or history of overt HE - History of shunt surgery or transjuglar intrahepatic portosystemic shunt for portal hypertension -Electrolyte imbalance - Evidence of infection at the time of enrollment -History of recent use (within one month) of drugs affecting psychometric performances like benzodiazepines, antiepileptics, or psychotropic drugs - Hepatocellular carcinoma - Severe medical problems such as congestive heart failure, pulmonary disease, or neurological or psychiatric disorder that could influence quality-of-life measurement; and inability to perform neuropsychological tests . - History of alcohol intake within last one month. - History of intake of lactulose,rifaximin, L-ornithine-L-aspartate or probiotics in last one month. - History of GI bleed in last one month, spontaneous bacterial peritonitis (SBP) on prophylaxis or hepatorenal syndrome (HRS). - Patients of acute on chronic liver failure (ACLF).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in Spectral EEG after Lactulose therapy. -Improvement in MHE after after Lactulose therapy Timepoint: Changes in Spectral EEG after 3 months of Lactulose therapy. -Improvement in MHE after after Lactulose therapy | — |
Secondary
| Measure | Time frame |
|---|---|
| --Improvement in CTP and MELD score. -Hospital admission -Mortality Timepoint: 3 months | — |
Countries
India
Contacts
Public ContactJatinderpal singh
GB Pant Hospital
Outcome results
None listed