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Brain stimulation targeting neurocognition and social functioning in schizophrenia

Efficacy of Adjunctive Neuro-Navigated continuous Theta Burst Stimulation on Working Memory, Emotion Recognition and Social Functioning in Schizophrenia: A Randomized, double-blind, sham controlled study with Gamma Oscillatory Activity as Neuro-physiological predictors for response

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2015/01/005448
Enrollment
45
Registered
2015-01-22
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- schizophrenia

Interventions

Intervention1: Active repetitive Transcranial Magnetic Stimulation (rTMS) : Active continuous theta burst repetitive Transcranial Magnetic Stimulation (rTMS)delivered using Magstim® Rapid2 device (Th

Sponsors

DEPARTMENT OF BIOTECHNOLOGY MINISTRY OF SCIENCE AND TECHNOLOGY UNDER INCRE FELLOWSHIP
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Diagnosis of Schizophrenia (F20.0-F20.9) according to ICD-10-DCR 2. Patients on a stable dose of antipsychotic medication 3. Patients of either sex aged between 18-60 years. 4. Right handed, normotensive patients. 5. Patients giving written informed consent. 6. Screened eligible for rTMS.

Exclusion criteria

Exclusion criteria: 1. Current neurological or any comorbid psychiatric disorders. 2. History of substance abuse (Except nicotine and caffeine) in the past one month. 3. History of epilepsy, significant head injury or any neurosurgical procedure. 4. Subjects with cardiac pacemakers or other metal parts in the body. 5. Subjects who have received ECT in past 6 months

Design outcomes

Primary

MeasureTime frame
Working Memory, Emotion Recognition and Social FunctioningTimepoint: Baseline and at the end of 2 weeks of post rTMS intervention—

Secondary

MeasureTime frame
spontaneous gamma oscillatory activity (GOA) and GOA evoked by online working memory and emotion recognition tasks and psychopathology scores PANSSTimepoint: Baseline and at the end of 2 weeks of post rTMS intervention—

Countries

India

Contacts

Public ContactProf VINOD K SINHA

CENTRAL INSTITUTE OF PSYCHIATRY

vinod_sinhacip@yahoo.co.in

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026