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A clinical trial to study the effects of two types of dressing, Limited access dressing and conventional dressing in patients with Non healing chronic ulcers.

HISTOLOGICAL AND BIOCHEMICAL STUDY OF GRANULATION TISSUE MODULATED BY NEGATIVE PRESSURE UNDER LAD

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2015/01/005419
Enrollment
84
Registered
2015-01-16
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Non healing chronic ulcers

Interventions

Intervention1: Limited access dressing: Negative pressure wound therapy and moist wound healing. Each LAD dressing can keep upto 10-15 days and Wounds were washed with saline daily through the ports w

Sponsors

Manipal univeristy
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Non diabetic chronic ulcers

Exclusion criteria

Exclusion criteria: Patients with collagen disorders, Leprosy patients, Pregnant women, Liver cirrhosis, HIV +ve patients.

Design outcomes

Primary

MeasureTime frame
Collagen content (Hydroxyproline) in the granulation tissueTimepoint: After 10 days of treatment—

Secondary

MeasureTime frame
hexosamine, total protein, and antioxidants [reduced glutathione (GSH), glutathione peroxidase (GPx), glutathione s-transferase (GST), catalase (CAT), thiol], wound surface pH, matrix metalloproteinase-2 (MMP-2), and oxidative biomarker malondialdhyde (MDA) were measured in the granulation tissue. Histopathologically, necrotic tissue, amount of inflammatory infiltrate, angiogenesis and extracellular matrix deposition (ECM) were studied to determine wound healing.Timepoint: After 10 days of treatment—

Countries

India

Contacts

Public ContactDr Pramod kumar

Kasturba medical college manipal

pkumar86@hotmail.com9901700052

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026