Skip to content

Can prophylactic use of ondansetron prevent the incidence of pruritus (itching) and postoperative nausea and vomiting caused by morphine used during anesthesia?

Prophylactic Administration of Ondansetron in Prevention of Intrathecal Morphine Induced Pruritus and Post-Operative Nausea and Vomiting in Patients Undergoing Caesarean Section.

Status
Unknown
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2015/01/005362
Enrollment
50
Registered
2015-01-07
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Parturients of ASA class I or II physical status scheduled for cesarean delivery under spinal anesthesia.

Interventions

Intervention1: Ondansetron: 4mg (2 ml) of ondansetron is given 30 minutes before the administration of spinal anesthesia and the patients were observed for its efficacy in reducing the intrathecal mor

Sponsors

Dr Ram Bhakta Koju
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Parturients of American Society of Anesthesiologists (ASA) class I or II physical status scheduled for caesarean delivery under spinal anaesthesia.

Exclusion criteria

Exclusion criteria: 1) Patients with known allergy to ondansetron, bupivacaine or morphine. 2) Patients with pruritogenic systemic disease, a coexisting skin disorder or preexisting pregnancy induced pruritus. 3) Patients with any contraindication for spinal anesthesia. 4) Patients who refused to participate in the study.

Design outcomes

Primary

MeasureTime frame
1) Incidence of pruritus and post operative nausea/vomiting Timepoint: Every 15 minutes for first 4 hours followed by 8 and 24 hours post surgery

Secondary

MeasureTime frame
1) Onset and Duration of pruritus 2) Severity of pruritus 3)Severity of post operative nausea / vomitingTimepoint: Every 15 minutes for first 4 hours followed by 8 and 24 hours post surgery

Countries

Nepal

Contacts

Public ContactRam Bhakta Koju

KIST Medical College

dr.koju@gmail.com977-9841113271

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Mar 5, 2026