Health Condition 1: null- Neonates undergoing major abdominal and thoracic surgeries
Conditions
Interventions
Intervention1: D1RL: Ringer Lactate with 1% Dextrose
Dose : at 10ml/kg/hr with additional allowance as per requirement
Duration : beginning to end of surgery
Intervention2: D2RL: Ringer Lactate with 2% Dextrose
Duration : beginning to end of surgery
Control Intervention1: DSRL: 10% dextrose in N/5 saline (maintenace fluid
Dose : 4ml/kg/hr)
+ Ringer lactate (replacement fluid
Dose : at 6ml/kg/hr with additional allowance as per requirement during surgery)
Duration : beginning to end of surgery
Sponsors
All India Institute of Medical Sciences
Eligibility
Inclusion criteria
Inclusion criteria: 1. Full term neonates 2. Emergency and elective surgery 3. Haemodynamically stable prior to surgery 4. Blood glucose and electrolyte concentration within normal range.
Exclusion criteria
Exclusion criteria: 1. Preterm 2. Infants of diabetic mothers 3. Inadequate optimisation (hydration, haemodynamics, blood glucose & electrolytes) in pre-operative period 4. Neonates with anticipated gross haemodynamic instability. 5. Neonates in whom arterial arterial cannulation is contraindicated or fails.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Arterial Blood Glucose comparisonTimepoint: Pre-operative and at the end of surgery | — |
Secondary
| Measure | Time frame |
|---|---|
| Acid-base parameters (pH, Base deficit, bicarbonate, lactate)Timepoint: Pre-operative and at the end of surgery;Biochemical parameters (free fatty acid, plasma ketone bodies)Timepoint: Pre-operative and at the end of surgery;Elctrolytes (sodium, potassium, chloride, bicarbonate, anion gap)Timepoint: Pre-operative and at the end of surgery;Endocrine stress markers (Glucagon, Insulin, Cortisol)Timepoint: Pre-operative and at the end of surgery | — |
Countries
India
Contacts
Public ContactPriyankar Kumar Datta
All India Institute of Medical Sciences
Outcome results
None listed