Comparison of ephedrine and phenylephrine for treatment of fall in blood pressure after spinal anaesthesia in preeclampsia patients undergoing caesarean section

Randomized double-blind comparison of ephedrine and phenylephrine for management of post spinal hypotension in preeclampsia patients undergoing caesarean section

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2014/12/005317

Enrollment

Registered

2014-12-19

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Spinal Anaesthesia induced Hypotension in Preeclampsia Patients

Interventions

Intervention1: Group Phenylephrine: Phenylephrine 50 mcg IV will be given for treatment of each episode of hypotension till the time of delivery Control Intervention1: Group Ephedrine: Ephedrine 4 mg

Eligibility

Inclusion criteria

Inclusion criteria: Preeclamptic females with singleton pregnancy undergoing caesarean section under spinal anaesthesia, Preeclampsia diagnosed as BP greater than or equal to 140/90 mmHg on two or more occasions at least 4 hrs apart and proteinuria greater than or equal to 300 mg/ 24 hrs or 1+ dipstick test. Post-spinal hypotension, defined as fall of SBP of greater than or equal to 20% from the baseline or an absolute SBP < 100mm Hg, whichever is higher

Exclusion criteria

Exclusion criteria: Maternal complications other than preeclampsia e.g. chronic hypertension, other cardiovascular disease, cerebrovascular disease; multiple gestation; known fetal abnormality; patients with absolute or relative contra-indications for spinal anaesthesia e.g. infection in lumbar area, coagulation abnormalities, platelet count < 75000/cumm, autonomic neuropathy, spinal deformities, other neurological diseases, hypovolemia due to any cause; severe fetal distress or other conditions requiring immediate induction of general anaesthesia

Design outcomes

Primary

Measure	Time frame
Umbilical artery pHTimepoint: Till the time of delivery of baby	—

Secondary

Measure	Time frame
APGAR scores at 1 and 5 minutes,Incidence of fetal acidosis (defined as umbilical artery pH less than 7.20), Number of vasopressor boluses given, Number of episodes of hypotension, Incidence of tachycardia/bradycardia/arrhythmias/hypertension, Incidence of nausea, vomiting, dizziness or any other complications Timepoint: Till the time of delivery of baby	—

Countries

India

Contacts

Public ContactDr Medha Mohta

University College of Medical Sciences and Guru Teg Bahadur Hospital

drsakshiduggal@gmail.com9911343428

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026