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Evaluation of analgesic action of morphine given in peripheral tissues in patients undergoing major spine surgery.

Evaluation of peripheral analgesic action of morphine in patients undergoing major spine surgery-A Randomized Controlled Trial

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2014/12/005315
Enrollment
100
Registered
2014-12-18
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Patient with or without mild systemic disease (ASA I and II),undergoing major spine surgery with surgical duration upto 4 hours

Interventions

Intervention1: Group II: Incision site infiltration with bupivacaine 0.25 %, total volume of infiltration will be 20-ml Intervention2: Group III: Incision site infiltration with bupivacaine 0.25 % + M

Sponsors

Department of Anaesthesiology Pain and Perioperative Medicine
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.ASA I/II 2.Age 20-65 years 3.Weight of >45 kg to 4.Major Spine surgery 2 to 4 levels,with or without fixation.

Exclusion criteria

Exclusion criteria: 1. Consent refusal 2. Body-weight: 75 kg 3. Allergic to opioids/local anaesthetics 4. Any decompensating systemic illness (renal, hepatic, cardiac, respiratory, etc.) 5. Coagulation disorder 6. Neurologic/psychiatric disorder/drug dependence/substance abuse 7. ASA physical status: III/IV 8. Inadvertent dural-rent during surgery 9. Blood loss necessitating transfusion 10. Prolonged surgical duration (>=4-hours) 11. Perioperative ionotrope/vasopressor use 12. Need for elective postoperative ventilation 13. History of previous spine surgery

Design outcomes

Secondary

MeasureTime frame
1. Total IV-PCA fentanyl consumption 2. Side effects (respiratory distress, nausea, vomiting, etc.) specific to morphine infiltration 3. Patient satisfaction Timepoint: Extubation to 72 hours after the procedure—

Primary

MeasureTime frame
1. Peripheral morphine analgesia assessment 2. Time-to-first rescue analgesia 3. The requirement of postoperative intravenous patient-controlled analgesia (IV-PCA) Timepoint: Extubation to 72 hours after the procedure—

Countries

India

Contacts

Public ContactBhuwan Panday

Department of Anaesthesiology,Pain and Perioperative Medicine

bhuwancp@gmail.com01142252513

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026