None listed
Conditions
Interventions
Intervention1: True Transcranial Current Stimulation: Actual Brain Stimulation Technique. The stimulation level will be set at 2 mA for 20 minutes. The sessions will be conducted twice a day for 5 con
Sponsors
National Institute of Mental Health and Neurosciences
Eligibility
Inclusion criteria
Inclusion criteria: 1) Diagnosis of schizophrenia / schizophreniform disorder as per DSM-V criteria (Diagnostic and Statistical Manual for Mental Disorders, American Psychiatric Association, 2013); 2) Clinically Significant Auditory Verbal Hallucinations as defined by the Auditory Hallucination Rating Scale (Haddock et al., 1999) items on frequency, duration and disruption each having a score >= 2; 3) Persistence of Auditory Verbal Hallucinations as denoted by daily hallucinations without remission despite adequate treatment with antipsychotic medication at an adequate dosage for at least 3 months (Brunelin et al., 2012a) 4) Age range: 18 â?? 45 years; 5) Both sexes; 6) Right Handedness and 7) Written informed consent.
Exclusion criteria
Exclusion criteria: 1. Features suggestive of psychiatric emergency (for example: suicidal risk, aggression, excitement, catatonia, prolonged nutritional deprivation or any other status requiring intensive clinical care) 2. Pregnancy or post-partum status 3. Any contraindication to tDCS procedure (metal in the head, implanted brain medical devices, local lesion or injury in the scalp / head) 4. Any contraindication for MRI 5. Any co-morbid psychiatric or neurological diagnosis 6. Left/Mixed Handedness
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Degree of reported auditory verbal hallucination 2. Corollary discharge mechanism (An event-related potential paradigm) 3. P3a/MMN complex (An event-related potential paradigm) 4. Fronto-temporo-parietal connectivity (Rest-fMRI)Timepoint: Twice. Before intervention and after intervention | — |
Secondary
| Measure | Time frame |
|---|---|
| CognitionTimepoint: Twice. Before intervention and after intervention | — |
Countries
India
Contacts
Public ContactAnushree Bose
National Institute of Mental Health and Neurosciences
Outcome results
None listed