The Effect of Blood Pressure improvement on memory function of Senior Citizens with Low Blood Pressure and mild memory impairment.

The Effect of Blood Pressure Normalization Interventions on Cognitive function of Senior Citizens with Low Blood Pressure and Mild Cognitive Impairment. - BP Norm cog study

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2014/12/005298

Enrollment

Registered

2014-12-16

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Low Blood Pressure and Mild Cognitive Impairment.

Interventions

Intervention1: Fludrocortisone.: â?¢For those on antihypertensive therapy: Gradual reduction in dosage of blood pressure lowering agent/agents at weekly intervals. until target BP 130/70 is achieved

Eligibility

Inclusion criteria

Inclusion criteria: 1. Senior citizens >65 years. 2. Cognitive scores between20-27(using MOCA) 3. Blood pressure

Exclusion criteria

Exclusion criteria: 1. Acute illness. 2. Moderate to severe dementia 3. Diseases with hemodynamic instability. 4. Uncontrolled diabetes 5. Depression 6. Delirium. 7. Total illiteracy.

Design outcomes

Secondary

Measure	Time frame
1. Percentage of participants in intervention group with edema, hypokalemia, elevated blood pressure of â?¥160/90 on Fludrocortisone. 2. Occurrence of any serious adverse event. Timepoint: 1.Safety visits to look for adverse effects. 2.MOCA,KMMSE scores are assessed at beginning,after 4 weeks and end of study.	—

Primary

Measure	Time frame
1. Improvement in mean cognitive scores of MOCA/ kannada translated Hindi MMSE before and after intervention among intervention and control groups. 2. Percentage of people with improvement in cognitive scores of â?¥ 3 among intervention and control groups. 3. Percentage of participants in intervention group with edema, hypokalemia, elevated blood pressure of â?¥160/90 on Fludrocortisone. 4. Occurrence of any serious adverse event. Timepoint: Percentage of people with improvement in cognitive scores of â?¥ 3 among intervention and control groups.	—

Measure

Time frame

1. Improvement in mean cognitive scores of MOCA/ kannada translated Hindi MMSE before and after intervention among intervention and control groups. 2. Percentage of people with improvement in cognitive scores of â?¥ 3 among intervention and control groups. 3. Percentage of participants in intervention group with edema, hypokalemia, elevated blood pressure of â?¥160/90 on Fludrocortisone. 4. Occurrence of any serious adverse event. Timepoint: Percentage of people with improvement in cognitive scores of â?¥ 3 among intervention and control groups.

—

Countries

India

Contacts

Public ContactDR PRABHA ADHIKARI

KMC MANGALORE MANIPAL UNIVERSITY

prabharaghuveer@gmail.com9880991290

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026