Health Condition 1: null- Infertility
Conditions
Interventions
Intervention1: clomiphene-gonadotropin ovulation induction cycles with Cetrorelix: Cetrorelix as 0.25mg subcutaneously is the intervention drug studied in two different regimens given in clomiphene ci
Sponsors
None listed
Eligibility
Inclusion criteria
Inclusion criteria: 1)Unexplained infertility; 2)Mild male factor infertility; 3)Ovulation dysfunction infertility with previously failed induction with letrozole or clomiphene; 4)At least one patent fallopian tube; 5)BMI 18.5â??29.9 kg/m2 6)Euthyroid state 7)No associated medical problems like diabetes mellitus or Hypertension or Drug allergies.
Exclusion criteria
Exclusion criteria: 1)Severe male factor infertility; 2)Stage III or IV endometriosis; 3)Tubal Factor Infertility; 4)baseline FSH >12 IU/L; 5)Less than four antral follicles per ovary
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1.Premature luteinization rate 2.Ovulation ratesTimepoint: 1. If LH more than 10 mIU/ml and Progesterone more than 2ng/ml on day 10 and/or day 12 of menstrual cycle 2. Documented by transvaginal ultrasound after 36 hours of ovulation trigger | — |
Secondary
| Measure | Time frame |
|---|---|
| 1.Pregnancy rate 2.Endometrial thickness 3.Adverse effects like ovarian hyperstimulation syndrome and multiple pregnancies 4.Cycle cancellation rate Timepoint: 1.Positive urine pregnancy test after 15 days of IUI 2.Thickness measurement on the day of dominant follicle (more than or equal to 18 mm size) 3.Checked on the day of positive urine pregnancy test or in a symptomatic patient 4.If no dominant follicle by day 18 of the cycle | — |
Countries
India
Contacts
Public ContactDr Devendra siva karthikS
All India Institute of Medical Sciences
Outcome results
None listed