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Low volume respiration during operation in patients with infection in abdomen

Intraoperative lung protective ventilation in peritonitis patients undergoing emergency laparotomy: A randomized controlled trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2014/12/005256
Enrollment
60
Registered
2014-12-05
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Peritonitis patients undergoing emergency laparotomy

Interventions

Intervention1: Low tidal volume: Patients receiving protective lung ventilation with tidal volume 6 to 8ml/kg and PEEP 6 to 8cm H2O, along with recruitment maneuvers (30 cm H2O for 30 seconds) every h

Sponsors

AIIMS New Delhi
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Age > 18 yrs, Emergency laparotomy expected duration >2hrs Suspected or identified abdominal source of infection Preoperative risk index for pulmonary complications >2

Exclusion criteria

Exclusion criteria: Mechanical ventilation within 2 weeks preceeding surgery BMI >= 35 History of respiratory failure or sepsis within the 2 weeks preceding surgery Requirement for intrathoracic surgery, history of lung surgery History of severe COPD, with (non-invasive) ventilation and/or oxygen therapy at home and/or repeated systemic corticosteroid therapy for acute exacerbations of COPD Progressive neuromuscular illness ALI or acute respiratory distress syndrome expected to require prolonged post-operative mechanical ventilation, Persistent hemodynamic instability or intractable shock

Design outcomes

Primary

MeasureTime frame
Pulmonary complications occurring by day 7 after surgery in the form of acute respiratory failure, Pneumonia,ARDS, Pneumothorax Timepoint: Pulmonary complications occurring by day 7 after surgery in the form of acute respiratory failure, Pneumonia,ARDS, Pneumothorax—

Secondary

MeasureTime frame
1. Pulmonary complications graded on a scale 0 to 4 2. Ventilation related adverse events during surgery 3. Severe sepsis, septic shock, organ dysfunction 4. Number of days of ICU admission and duration of hospital stay 5. Surgical complications like development of intraabdominal abscess, anastomotic leakage, unplanned re-exploration Timepoint: Within 7 days of surgery—

Countries

India

Contacts

Public ContactDr Dalim Kumar Baidya

All India Institute of Medical Sciences, New Delhi

dalimkumarb001@yahoo.co.in9868398013

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026