â?¢ To assess the in-vivo ability of local anesthetics agents like lignocaine to decrease the dissemination of cancer cells during surgery and improve the disease free interval

Randomized controlled trial to assess blockade of voltage gated sodium channels during surgery in operable breast cancer.

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2014/11/005228

Enrollment

1600

Registered

2014-11-28

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Operable Female Breast Cancer

Interventions

Intervention1: Peritumoural Injection 0.5 % Lignocaine: 60mM of 0.5% lignocaine will be injected peritumoral prior to excision. The local anesthetic should be injected on all 6 surfaces of the tumor a

Eligibility

Inclusion criteria

Inclusion criteria: ï?? All women with operable breast cancer planned for upfront surgery ï?? Histologically proven or clinically suspicious breast cancer

Exclusion criteria

Exclusion criteria: ï?? Previous h/o lumpectomy or incision biopsy ï?? Distant metastases ï?? Neoadjuvant Chemotherapy ï?? H/o allergy to drugs (lignocaine) ï?? High risk factors precluding the use of lignocaine ï?? Previous history of cancer

Design outcomes

Primary

Measure	Time frame
Disease-free survivalTimepoint: 5 yrs	—

Secondary

Measure	Time frame
Improvements in overall survivalTimepoint: 5 yrs	—

Countries

India

Contacts

Public ContactMs Rohini Hawaldar

Tata Memorial Hospital

vaniparmar@gmail.com91-22-24177194

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 9, 2026