A clinical trial to study the effect of vitamin D in improving the symptoms of heartburn and regurgitation in patients with Gastroesophageal reflux disease

Effect of vitamin D and calcium supplementation on the esophageal motor function assessed by manometry in patients with Gastro esophageal reflux disease - A randomized double blinded placebo controlled cross over clinical trial

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2014/11/005183

Enrollment

Registered

2014-11-07

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- patients with gastro esophageal reflux disese and vitamin D deficiency

Interventions

Intervention1: Vitamin D (Cholecalciferol)and oral calcium: Injection Arachitol 600000 IU intramuscular stat Oral Calcium citrate maleate 500 mg BD for 30 days Control Intervention1: Identical looking

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients diagnosed with Gastroesophageal reflux disease based on the clinical diagnostic criteria 2. Patients giving consent for their inclusion in the study 3. BMI

Exclusion criteria

Exclusion criteria: 1. Patient previously operated for GERD 2. Patients who have received mega doses (6,00,000 IU) of Vit D in the last 6 months 3. Patients having Peptic stricture, GOO, primary Systemic Sclerosis, Endoscopic Sclerotherapy, EVL, Esophageal varices 4. Women who are pregnant/lactating or planning conception; students; trainees; mentally retarded; institutionalised subjects

Design outcomes

Primary

Measure	Time frame
Esophageal motor function Improvement in symptomatologyTimepoint: 4 weeks	—

Secondary

Measure	Time frame
Improvement of quality of life Improvement in skeletal muscle functionTimepoint: 4 weeks	—

Countries

India

Contacts

Public ContactKodati Rakesh

PGIMER

ushadutta@gmail.com8198877022

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026