Efficacy of Dexmedetomidine given through epidural space in improving oxygenation and shunt fraction in patients undergoing lung surgery via chest wall thoracotomy.

Title-â??The Effect of Epidural dexmedetomidine on oxygenation and shunt fraction in patients undergoing thoracotomy and one lung ventilationâ??

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2014/11/005182

Enrollment

Registered

2014-11-07

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: J00-J99- Diseases of the respiratory system Health Condition 2: null- Patients undergoing thoracotomy and one lung ventilation

Interventions

Intervention1: RD group: In the Intervention group 1mcg/kg of Dexmedetomidine with 0.5% Ropivacaine in a volume of 7ml will be used for bolus epidural infusion This will be followed by infusion of dex

Eligibility

Inclusion criteria

Inclusion criteria: 18-60 yrs, ASA I-II patients undergoing Thoracotomy and one lung ventilation for lung surgery.

Exclusion criteria

Exclusion criteria: Contraindication to Epidural anaesthesia, Known allergy to study drugs, Documented severe cardiovascular disease, H/o Myocardial infarction, arrhythmias, Hypertensives on treatment with alpha2 agonists, Severe neuropsychiatric disease, renal dysfunction(S.cr >1.5gm/dl), Hepatic dysfunction, Long term alcohol or other drug addiction. Intraoperative exclusion criteria- If Spo2 decreased to

Design outcomes

Primary

Measure	Time frame
Oxygenation(PaO2) and shunt fraction(Qs/Qt)Timepoint: 15 minutes after two lung ventilation (TLV15) 15 and 45 minutes after one lung ventilation (OLV15, OLV45) Reinstitution of TLV (ReTLV)	—

Secondary

Measure	Time frame
1.Induction dose of Propofol, 2.Heart rate, systolic, diastolic,Mean arterial pressure, Central venous pressure, Entropy values and End tidal sevoflurane concentrationTimepoint: 1.At induction 2. 1,2,5 minutes after intubation, TLV15, OLV15, OLV45, Re TLV	—

Countries

India

Contacts

Public ContactDr Prachi Kar

Nizams Institute of Medical Sciences

prachikar@yahoo.co.in07702897765

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026