Clonidine as an additive to local anaesthetic injections around scalp.

A prospective, comparative, randomized, double blind study to evaluate the safety and efficacy of scalp block with bupivacaine and clonidine versus bupivacaine only for supratentorial craniotomies.

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2014/10/005151

Enrollment

Registered

2014-10-29

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- ASA I and II patients

Interventions

Intervention1: Clonidine: Addition of 2mcg/kg clonidine to 20cc of 0.25% bupivacaine in scalp block Control Intervention1: Bupivacaine 0.25% only: Plain scalp block with 20 ml of 0.25% bupivacaine

Eligibility

Inclusion criteria

Inclusion criteria: 1] 60 ASA I and II patients 2] Age 18yrs to 65 yrs 3] Glasgow coma scale 15/15 4] Patients undergoing supratentorial craniotomies under general anaesthesia

Exclusion criteria

Exclusion criteria: 1] Emergency cases 2] Patients with uncontrolled hypertension 3] Ischaemic heart disease or cardiac arrhythmias 4] Hepatic or renal disease 5] severe pulmonary disease 6] chronic alcoholism and chronic drug abusers 7] History of craniotomy 8] History of drug allergy to local anaesthetics and/or clonidine 9] patients on alpha blockers preoperatively 10] patient refusal

Design outcomes

Primary

Measure	Time frame
Duration of postoperative analgesiaTimepoint: 24 hours	—

Secondary

Measure	Time frame
Complications like bradycardia, hypertension etc.Timepoint: intraoperative;Intraoperative haemodynamicsTimepoint: Every 5 minutes from skin incision to dura opening and dura closure to skin suturing;Intraoperative requirement of fentanylTimepoint: intraoperative	—

Countries

India

Contacts

Public ContactAnjana

King Edward Memorial Hospital.

anjanawajekar@gmail.com9930104106

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026