Health Condition 1: null- Patients with convulsive status epilepticus. Recruited patients received i.v. lorazepam within 5 min. of arrival to the emergency services and then randomized into 3 groups.
Conditions
Interventions
Intervention1: Phenytoin: group 1: The PHT group received intravenous phenytoin sodium (Epsolin) - 20 mg/kg (800-1600 mg) in 100 ml normal saline infused immediately at a rate of 50 mg/minute followed
Sponsors
NON FUNDED
Eligibility
Inclusion criteria
Inclusion criteria: 1. Consecutive patients presented to NIMHANS emergency services with convulsive SE (more than 30 minutes of continuous convulsive seizure activity or two or more sequential seizures without full recovery of consciousness in between seizures) 2. All underlying etiology of SE 3.All the 150 recruited patients with GCSE received intravenous lorazepam (0.1 mg/kg; 4-6 mg) within 5 minutes of arrival to the emergency services. 4.consented for the study 5.age group between 15-65 years were included
Exclusion criteria
Exclusion criteria: unwilling patients, patients presenting with non-convulsive SE, liver failure, renal failure, cardiac disease, pregnancy, requiring urgent neurosurgical intervention, H/O allergy to drugs, patients treated outside with AEDs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary outcome was seizure controlTimepoint: Control of SE: a) No recurrence of seizures after 30 minutes of AED infusion with substantial improvement in sensorium over next 24 hours; or b) Sensorium did not improve substantially but EEG excluded NCSE. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcomes were mortality, morbidity, side effects, and seizure control at 1 monthTimepoint: at discharge from hospital and at 1 month | — |
Countries
India
Contacts
Public ContactSanjib Sinha
NIMHANS
Outcome results
None listed