Health Condition 1: null- non-severe dengue patients.
Conditions
Interventions
Intervention1: Dengue patients on standard treatment and Carica papaya leaf extract capsule [PAPAYUR (Papaya leaf extract 10:1,600mg capsule] supplied by BIOEXTRACT.600 mg capsule two times a day oral
Sponsors
Jawaharlal Institute of Post graduate Medical Education and Research JIPMER
Eligibility
Inclusion criteria
Inclusion criteria: ï?? Dengue Fever Subjects 18-60 yrs positive for dengue NS1 antigen or anti IgM/IgG dengue antibodies or virus by Reverse Transcriptase PCR.
Exclusion criteria
Exclusion criteria: ï?? Dengue fever group C and those with bleeding manifestations other than petechiae/purpura ï?? Pregnant or lactating women. ï?? Known case with hepatic and renal diseases. ï?? Patients with inherited platelet disorders ï?? Patients on medications which interfere with platelet function (NSAIDs) will be excluded from the study. ï?? History of allergic reactions to papaya. ï?? Patients with more than 2 episodes of vomiting in the past 24 hours.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| supplementation of papaya leaf extract to dengue patients increases platelet aggregation,decreases membrane fluidity and p-selectin expressionTimepoint: 1st day, 3rd day and 7th day of start of intervention | — |
Secondary
| Measure | Time frame |
|---|---|
| Improvement in platelet count and hematocrit value.Timepoint: 0,3rd and 7th day | — |
Countries
India
Contacts
Public ContactDr R SOUNDRAVALLY
Jawaharlal Institute of Post graduate Medical Education and Research (JIPMER)
Outcome results
None listed