Health Condition 1: I607- Nontraumatic subarachnoid hemorrhage from unspecified intracranial artery Health Condition 2: I607- Nontraumatic subarachnoid hemorrhage from unspecified intracranial artery Health Condition 3: null- Ptients who have suffered from intracranial aneurysm rupture undergoing clipping to prevent rebleed are being studied
Conditions
Interventions
Intervention1: DESFLURANE
: dose: 4-6% (to keep entropy values between 40-60)
route: inhalational
frequency: administered continuously throughout the surgery for maintenance of anaesthesia.
relatively
Sponsors
PGIMER
Eligibility
Inclusion criteria
Inclusion criteria: Hunt and Hess Grade I-III and WFNS Grade I-II ASA I-III (including patients with hypertension & Diabetes mellitus)
Exclusion criteria
Exclusion criteria: (1)Posterior circulation aneurysm (2)Any comorbidities other than hypertension or diabetes (i.e. Coronary artery Disease, COPD, Hepatic and Renal impairment) (3) Patients in septic shock (4) Prolonged surgery ( >5 hours) (5)Intra operative adverse event causing hemodynamic instability
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| duration of hospital stay after surgery and condition at the time of discharge as assessed by modified ranikin scaleTimepoint: duration of hospital stay after surgery and condition at the time of discharge as assessed by modified ranikin scale | — |
Secondary
| Measure | Time frame |
|---|---|
| any post op nausea or vomiting and neurological deficits in both the groupsTimepoint: 5 hr;condition at 24 hours after surgery in terms of glasgow coma score and neurological deficitTimepoint: 24 hrs;intra operative brain relaxation in both the groups.Timepoint: at dura opening 1 hr;intra operative jugular bulb saturation in both the groupsTimepoint: 1,2,3,4 hrs;time to eye opening, extubation & following verbal commands in both the groupsTimepoint: 5 hrs | — |
Countries
India
Contacts
Public ContactAVANISH BHARDWAJ
PGIMER, CHANDIGARH
Outcome results
None listed