Health Condition 1: null- Uncomplicated Plasmodium falciparum malaria
Conditions
Interventions
Intervention1: artesunate sulphadoxine-pyrimethamine supervised or non-supervised: sulphadoxine-pyrimethamine,primaquine either in supervised or non-supervised therapy
Intervention2: artesunate sulpha
Sponsors
Dr Chiranjib Bagchi Calcutta School of Tropical Medicine
Eligibility
Inclusion criteria
Inclusion criteria: Inclusion Criteria • Presence of acute symptomatic uncomplicated malaria with a diagnosis confirmed by a positive blood smear with asexual forms of P falciparum parasites only (without mixed infection). • Only those of the above patients considered eligible by the physician at the Malaria Clinic, for dispensation of AS-SP plus primaquine treatment as per the national guidelines (NVBDCP). • Adult patients (age > 18 years) â?? both sexes • Patients willing to give informed consent. • Patients considered able to comply with the study protocol for the duration of the study. • Patients residing within a reasonable distance of the site, so that attendance of all study visits and follow-up by medical staff are logistically feasible.
Exclusion criteria
Exclusion criteria: Exclusion Criteria • Mixed infection with another Plasmodium species at the time of presentation (including P vivax, P ovale and P malariae) • Known allergy to artesunate, artemisinin derived products, sulphadoxine, pyremethamine, primaquine or any other related drugs. • G6PD deficiency as investigated by the G6PD test
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Adherence of patients to artesunate/sulphadoxine-pyrimethamine treatmentTimepoint: Adherence, Serum antimalarial estimation- on Day 3 | — |
Secondary
| Measure | Time frame |
|---|---|
| Compare efficacy and tolerabilityTimepoint: Day 0,3,7,28 | — |
Countries
India
Contacts
Public ContactDr Chiranjib Bagchi
Calcutta School of Tropical Medicine
Outcome results
None listed