Health Condition 1: null- neonates requiring PRBC transfusion
Conditions
Interventions
None listed
Sponsors
PGIMER
Eligibility
Inclusion criteria
Inclusion criteria: Neonates (term up to 28 days of age and preterm up to corrected age of four weeks) admitted in Newborn unit requiring PRBC transfusion for anemia
Exclusion criteria
Exclusion criteria: • Life threatening congenital malformations • Neonates with immune hemolytic condition (defined as a positive Direct Coombâ??s test, exaggerated reticulocyte response or peripheral smear showing evidence of hemolysis) • Previous â??out of studyâ?? blood transfusions (neonates who have already received PRBC transfusion before being screened for the study) would be excluded. However neonates who have received blood transfusion previously as a part of study and require PRBC transfusion again would be eligible for inclusion. • Parents not willing to participate in the study and hence refused consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| â?¢Percent rise in hematocrit at 15 minutes after PRBC transfusion.Timepoint: 15 min | — |
Secondary
| Measure | Time frame |
|---|---|
| â?¢ Percent rise in hematocrit at 6 hours after PRBC transfusion. â?¢ Factor affecting the rise of hematocrit â?¢ Percent rise in hematocrit at15 min, 6 hours and 24 hours of G6PD deficient PRBC transfusion â?¢ To study the evidence for hemolysis i.e, peripheral blood smear, reticulocyte count, plasma hemoglobin and rise in total serum bilirubin after 24 hours with G6PD deficient PRBC transfusion. Timepoint: 6 hour and 24 hours | — |
Countries
India
Contacts
Public ContactDr Sourabh Dutta
Advanced Pediatric Centre PGIMER
Outcome results
None listed