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A comparative study to find out the effectiveness of dexmedetomidine and midazolam with propofol alone for sedation during awake fibreoptic nasotracheal intubation

To evaluate the efficacy and safety of dexmedetomidine and midazolam with propofol alone for sedation during awake fibreoptic nasotracheal intubation

Status
Active, not recruiting
Phases
Phase 3Phase 4
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2014/10/005093
Enrollment
40
Registered
2014-10-13
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Patients of either sex aged between 18 and 60 years belonging to ASA grade I& II scheduled for elective surgery

Interventions

Intervention1: I/v midazolam 0.02 mg/kg followed by dexmedetomidine 1 ug/kg infusion over 10 minutes,then an infusion of dexmedetomidine 0.1ug/kg/hr and titrated to 0.7 ug/kg/hr: Group I patientS will

Sponsors

Government Medical college Rajindra Hospital Patiala
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients of either sex aged between 18 and 60 years belonging to ASA physical status of I & II grade,scheduled for elective surgery at Rajindra Hospital,Patiala

Exclusion criteria

Exclusion criteria: .History of severe bradycardia .Any type of A-V block in ECG .Heart failure .Liver cirrhosis .Thrombocytopenia .Coagulopathy .History of hypertension/diabetes mellitus/bronchial asthma .History of previous nasal surgery/nasal trauma .Nasal polyp .Prisoners .Pregnant females .Mentally ill patients .Drug abusers

Design outcomes

Primary

MeasureTime frame
.Ease of placement OF fibreoptic scope and endotracheal tube .Comfort scale values like alertness,calmness,respiratory response,crying,physical movement,muscle tone,facial tension .patients tolerance .patients experience with awake fibreoptic intubationTimepoint: 0 and 24 hours after surgery

Secondary

MeasureTime frame
any adverse eventsTimepoint: during intubation and 24 hours after surgery

Countries

India

Contacts

Public ContactDr Namita Mishra

Government Medical College & Rajindra Hospital, Patiala

tspunia@yahoo.com9216323131

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026