Health Condition 1: null- Patients of Advanced Lung cancer
Conditions
Interventions
Intervention1: Chemotherapy
: 1. Paclitaxel â??Dose -80mg/m2 IV once weekly
2. Docetaxel â??Dose-75mg/m2 IV once in every 3 weeks
3.
Gemcitabine-Dose -1000mg/m2 IV day1and day 8, every 3 weeks
4.
Sponsors
Tata Memorial Hospital
Not Available at present
Eligibility
Inclusion criteria
Inclusion criteria: Inclusion criteria : TKI-naive patients with documented stage IIIB ( treated with palliative intent) or stage IV NSCLC who have progressed on first and second line chemotherapy regimens .2. ECOG Performance status (PS) from 0 to 2 3. Age >= 18yrs 4. Adequate bone marrow tests (absolute neutrophil count >1500/lL, hemoglobin > 8 g/dL, and platelet count >100,000/lL), renal function tests (creatinine 5. Life expectancy >= 3 months 6. Clinically stable brain metastases if any
Exclusion criteria
Exclusion criteria: Exclusion criteria: 1.Prior therapy with TKI 2.Patients with EGFR mutation 3. A second primary tumor 4. Uncontrolled infection 5.Uncontrolled co-morbidities
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary â?? Study the QOL in these two regimesTimepoint: At 8-10 Weeks at every OPD visits | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Safetyand Toxicity of these two regimens 2. PFS and OS in these two regimens Timepoint: 1. At every follow up visit 2. At the end of the study | — |
Countries
India
Contacts
Public ContactDr Kumar Prabhash
Tata Memorial hospital
Outcome results
None listed