Health Condition 1: null- Stroke
Conditions
Interventions
Intervention1: Mononuclear stem cells: average 60 million cells infused intravenously over three hours.
(1-2 million /kg body weight)
one single infusion.
Control Intervention1: Physical therapy: Virt
Sponsors
Department of Science and Technology
Eligibility
Inclusion criteria
Inclusion criteria: • Patients diagnosed with stroke of MCA territory within 3 months to two years of index event. • Age: 18-65 years. • Brunnstrom stage ; II to IV • MRC (Medical Research Council) grade of wrist and hand muscles of at least > 2. • NIHSS (National Institute of health stroke scale) of between 4 and 12. • Conscious and able to comprehend.
Exclusion criteria
Exclusion criteria: • Active Infection • Immunocompromised state • history or laboratory results indicative of any significant cardiac, endocrine, hematologic, hepatic, immunologic, infectious, metabolic, urologic, pulmonary, gastrointestinal, dermatologic, psychiatric, renal, or other disorders • neoplastic diseases ; malignancy • Autoimmune disorders • Immune-compromised subjects • Progressive neurological worsening, Contraindication to MRI • Female patients with known pregnancy or at risk of pregnancy, positive urine pregnancy test at screening. • Any other reason that, in the opinion of the Principal Investigator, makes the participant unsuitable for participation in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| NIHSS, m BI, Fugl Meyer,Timepoint: baseine, 6 weeks and 6 months | — |
Secondary
| Measure | Time frame |
|---|---|
| Functional imaging and spectroscopyTimepoint: baseline, 6 weeks and one year | — |
Countries
India
Contacts
Public ContactDr Ashu Bhasin
All india institute of medical sciences
Outcome results
None listed