Health Condition 1: M865- Other chronic hematogenous osteomyelitis Health Condition 2: M845- Pathological fracture in neoplastic disease Health Condition 3: null- Segmental bone defects following resection of tumor, infection or trauma in children
Conditions
Interventions
Intervention1: operative treatment of bone loss with scaffolds loaded with stem cells: Bone defect will be freshened up after excising the sclerotic ends. The seeded scaffold loaded with directed mese
Sponsors
Department of Biotechnology
Eligibility
Inclusion criteria
Inclusion criteria: Children over one year of age with large bone defects following tumor resection post-traumatic bone loss, post infective bone loss or loss due to any other causes with a good intact soft tissue envelope and giving consent for the experimental treatment
Exclusion criteria
Exclusion criteria: i) Active infection ii) Poor soft tissue cover iii) Patients who are not likely to come for a full review process of 2 years iv) Patients who are not likely to survive for 2 years due to their disease process
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Radiographic union of the grat at both ends Any major adverse eventTimepoint: follow ups at 2 weeks after surgery. seusequently 2 months, 3 months, 6 months, 9 months, one year, one and half years and 2 years | — |
Secondary
| Measure | Time frame |
|---|---|
| 1.To assess the osteoblastic activity in serum. 2. pixel assessment and CT assessemt after implant removalTimepoint: Bone specific alkaline phosphatase at 2weeks and 2 months | — |
Countries
India
Contacts
Public ContactDr Vrisha Madhuri
Christian Medical College Vellore
Outcome results
None listed