Anticaries effect of Probiotic tooth paste

Comparative study of topical effects of Probiotics with a commercial fluoride tooth paste in reducing dental caries in patients with higher salivary Streptococcus mutans levels.

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2014/09/005019

Enrollment

Registered

2014-09-15

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- patients with increased caries susceptibility, Salivary Streptococcus mutans level more than 5 million CFU/ml of saliva

Interventions

Intervention1: Lactic acid bacillus 200 million spores tablet incoporated in 100 grams tooth paste: Probiotic Lactobacillus strain in tooth paste form is given for patient with high caries susceptibil

Eligibility

Inclusion criteria

Inclusion criteria: patients with Streptococcus mutans CFU/ml above 5 million/ml of saliva and DMF index above 5

Exclusion criteria

Exclusion criteria: patients with Streptococcus mutans CFU/ml below 5 million/ml of saliva and DMF index below 5 and edentulous patients

Design outcomes

Primary

Measure	Time frame
Outcome is measured by decrease in Streptococcus colony forming units / ml of salivaTimepoint: After 15 days usage of tooth paste.	—

Secondary

Measure	Time frame
Increase in salivary flow rate, increase in salivary pH, increase in plaque pH. No risk of mortality.Timepoint: 15 days after tooth paste usage.	—

Countries

India

Contacts

Public ContactSanthosh Kumar

Ragas dental college and hospital

dr_kailasam@hotmail.com9840796200

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026