Health Condition 1: null- 1. Male or female arriving in ICU within 24 hours of trauma 2. 18 â?? 65 years of age
Conditions
Interventions
Intervention1: NGAL ELISA Kit: Upon admission, and at 24 and 48 hours, 2 ml of blood will be collected in EDTA anti-coagulated vacuettes and 2 ml urine will be collected and centrifuged at 800 x g for
Sponsors
Indian Council of Medical Research
Eligibility
Inclusion criteria
Inclusion criteria: 1. Male or female arriving in ICU within 24 hours of trauma 2. 18 â?? 65 years of age
Exclusion criteria
Exclusion criteria: • Age 65 years • Inability to obtain Informed Consent from patient or representative • > 24 hrs after insult • History of previous renal transplantation • Chronic kidney disease - known medical history with admitting serum Cr >1.4 mg% • Known or suspected ongoing pre-operative acute renal failure due to any cause, including pre-renal, intrinsic renal or post-renal (obstructive) etiologies (as evidenced by history, clinical presentation, USG, proteinuria (protein/creatinine ratio >0.5) in random urine sample and active urinary sediments , increasing serum creatinine or oliguria pre-operatively) • Already receiving dialysis • Any known or suspected renal ischemic insult(such as cardiac arrest) or nephrotoxic insult(other than intravascular contrast procedure) prior to admission • Cardiac arrest before and during enrolment • Transfer order within 24 hours • Probability of survival > 24 hours less likely • Transfer from other hospital • Severe head injury with Glasgow Coma Scale of 3
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| â?¢ To establish the diagnostic ability of plasma NGAL and urine NGAL to diagnose AKI (as per RIFLE criteria) as computed by sensitivity and specificity in trauma patients in surgical ICU. Time frame: 5 days after ICU admission Timepoint: 2 years 6 months | — |
Secondary
| Measure | Time frame |
|---|---|
| â?¢ Cut off value of plasma and urine NGAL for various stages of AKI â?¢ ICU stay â?¢ Need for RRT â?¢ Hospital Stay â?¢ Mortality Timepoint: 2 years 6 months | — |
Countries
India
Contacts
Public ContactDr Babita Gupta
AIIMS, New Delhi
Outcome results
None listed