EFFICACY OF GREEN TEA CATECHIN GEL LOCAL DRUG DELIVERY IN THE MANAGEMENT OF CHRONIC PERIODONTITIS PATIENTS

EVALUATION OF THE EFFICACY OF GREEN TEA CATECHIN GEL LOCAL DRUG DELIVERY IN THE MANAGEMENT OF CHRONIC PERIODONTITIS A QUASI EXPERIMENTAL STUDY

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2014/08/004925

Enrollment

Registered

2014-08-25

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- CHRONIC PERIODONTITIS

Interventions

Intervention1: LOCAL DRUG DELIVERY: 1 % GREEN TEA CATECHIN LOCAL DRUG DELIVERY ADMINISTERED SUBGINGIVALLY INTO PERIODONTAL POCKETS IMMEDIATELY AFTER SCALING AND ROOT PLANING AND DELIVERY CONTINUED AT

Eligibility

Inclusion criteria

Inclusion criteria: Systemically healthy patients diagnosed with generalised or localised chronic periodontitis More than three natural teeth each quadrant Probing pocket depth >= 5 mm in a minimum of one site each in two quadrants of the same arch Radiographic evidence of bone loss in sites with probing pocket depth >5 mm. Those willing to participate in the study

Exclusion criteria

Exclusion criteria: History of antibiotics in last 6 months History of periodontal therapy in last 6 months Psychological disorders Aggressive periodontitis Current smokers Immunocompromised patient Pregnant and lactating females Blood disorders Any other contraindication for periodontal surgery Diabetes Any other systemic disorders

Design outcomes

Primary

Measure	Time frame
Reduction in inflammation of periodontal tissues as measured by bleeding on probing, probing pocket depth, clinical attachment loss and gingival recession is expected to be significantly more in green tea catechin site compared to the placebo groupTimepoint: reevaluation at 11/2,3,6,9 months	—

Secondary

Measure	Time frame
Decrease in the need for surgical treatment in the test sites. Expression of MMP 9 in green tea catechin administered site is expected to be less compared to the expression in control site. Radiographic bone fill in green tea catechin administered pockets is expected to be more than the pockets in control site Timepoint: Decrease in the need for surgical treatment in the test sites after 11/2 months Expression of MMP 9 in test and control sites assessed at the time of surgery after 11/2 months Radiographic bone fill in test and control sites after 9 months	—

Measure

Time frame

Decrease in the need for surgical treatment in the test sites. Expression of MMP 9 in green tea catechin administered site is expected to be less compared to the expression in control site. Radiographic bone fill in green tea catechin administered pockets is expected to be more than the pockets in control site Timepoint: Decrease in the need for surgical treatment in the test sites after 11/2 months Expression of MMP 9 in test and control sites assessed at the time of surgery after 11/2 months Radiographic bone fill in test and control sites after 9 months

—

Countries

India

Contacts

Public ContactDR SEBA ABRAHAM

PMS COLLEGE OF DENTAL SCIENCE AND RESEARCH THIRUVANANTHAPURAM

sebapazhoor@pazhoor.com9447463676

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026