Health Condition 1: null- acute exacerbation of bronchial asthma with no other associated illness
Conditions
Interventions
Intervention1: corticosteroids: systemic corticosteroids
Intervention2: systemic corticosteroids: oral or parenteral corticosteroids
Sponsors
lady hardinge medical college new delhi
Eligibility
Inclusion criteria
Inclusion criteria: All diagnosed patients of bronchial asthma (age group 18-55 years of either sex) presenting with exacerbation, as defined by -patient breathlessness on slight walking/talking/at rest -patient able to talk in only words/phrases/incomplete sentences without breathlessness -respiratory rate >20 per minute -presence of wheezing on chest auscultation and undergoing treatment for the same, either on outdoor patient basis or admitted to a medicine unit of Smt. Sucheta Kriplani Hospital, New Delhi will be included in the study.
Exclusion criteria
Exclusion criteria: The following patients will be excluded from the study- i. Patient with any other co-existent and active pulmonary or non-pulmonary pathology. ii. Patient on drug treatment for any other concomitant disease or disorder. iii. Imminent respiratory arrest as indicated by- -Drowsy/confused patient. -Paradoxical thoraco-abdominal movements with respiration. -Absent wheeze. -Bradycardia (pulse iv. Evidence of active infection on chest X-ray. v. Patient who received systemic corticosteroid in last 4 weeks. vi. Patients who are contraindicated for systemic corticosteroids.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in serum levels of survivin and M 30 apoptosense in acute exacerbation of asthma patients on treatment with systemic corticosteroids.Timepoint: At the initiation of systemic corticosteroids, then 7 days later, and then depending upon improvement in symptoms 21 days thereafter | — |
Secondary
| Measure | Time frame |
|---|---|
| Correlation between asthma severity score as measured by SOA questionnaire and apoptotic marker level. Change in acute quality of life scores in asthma as measured by QOLtech AQLQ questionnaire, after treatment with systemic corticosteroids. Timepoint: At the initiation of systemic corticosteroids, then 7 days later, and then depending upon improvement in symptoms 21 days thereafter | — |
Countries
India
Contacts
Public ContactSHASHIKANT BHARGAVA
lady hardinge medical college, new delhi
Outcome results
None listed