Vitamin D and calcium and muscle strength

Vitamin D and calcium supplementation for improvement in skeletal muscle strength in young Asian Indian Males: A randomized controlled trial

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2014/07/004711

Enrollment

228

Registered

2014-07-03

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Cholecalciferol: The dose of cholecalciferol will be 60,000 IU/wk for first 8week followed by 60,000 IU twice a month for 4 months Intervention2: Calcium Carbonate: Calcium carbonate ta

Eligibility

Inclusion criteria

Inclusion criteria: 1. Age between 18 years and 25 years. 2. Currently residing in Delhi with commitment for follow-up for 6 months. 3. Written consent for randomization and supplementation after they have gone through project information sheet. 4: Apparently healthy with no history of chronic illness at any time or acute illness during the preceding two months.

Exclusion criteria

Exclusion criteria: 1. Subjects taking drugs which can affect bone mineral metabolism such as glucocorticoids, antitubercular, antiepileptics, levothyroxine, bisphosphonates, vitamin D and calcium supplementations 3. Those with history of any chronic renal or liver disorder or chronic diarrhea or any other chronic illness. 4. Subjects complaining of muscle aches and joint pain. 5. Serum total T4 and TSH suggestive of thyroid dysfunction.

Design outcomes

Primary

Measure	Time frame
Change in hand muscle grip strengthTimepoint: At six months of intervention	—

Secondary

Measure	Time frame
Change in circulating testosterone with supplementation Timepoint: Baseline and at six months;Change in hand grip strength with change in circulating testosterone after six months of intervention with cholecalciferol with and without calcium supplementation Timepoint: Baseline and at six months;Correlation of hand grip, pinch grip and six minutes walk distance with circulating testosterone at baselineTimepoint: Baseline	—

Measure

Time frame

Change in circulating testosterone with supplementation Timepoint: Baseline and at six months;Change in hand grip strength with change in circulating testosterone after six months of intervention with cholecalciferol with and without calcium supplementation Timepoint: Baseline and at six months;Correlation of hand grip, pinch grip and six minutes walk distance with circulating testosterone at baselineTimepoint: Baseline

—

Countries

India

Contacts

Public ContactDr Ravinder Goswami

Department of Endocrinology and Metabolism,All India Institute of Medical Sciences, New Delhi

gosravinder@hotmail.com26594272

Outcome results