Health Condition 1: null- Neonatal seizures
Conditions
Interventions
Intervention1: levetiracetam: babies will receive initial loading of i.v levetiracetam 20mg/kg over 20 minutes followed by loading doses of 20mg/kg upto maximum 60mg/kg if seizures are persistent. Mai
Sponsors
JIPMER
Eligibility
Inclusion criteria
Inclusion criteria: Babies admitted to NICU with clinical seizures and babies who develop clinical seizures during NICU stay with ï?§ Gestational age >= 32 wks ï?§ Birth weight >= 1500g ï?§ Chronological age
Exclusion criteria
Exclusion criteria: Babies admitted to NICU with seizures and babies who develop seizures during NICU stay with ï?§ Seizures due to hypoglycemia and hypocalcemia ï?§ Serum creatinine >2mg/dl ï?§ Major congenital anomalies ï?§ Prior use of any other anticonvulsants
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mortality and times taken for the clinical control of seizures upto 30 days of age or at discharge whichever is earlierTimepoint: Mortality and times taken for the clinical control of seizures upto 30 days of age or at discharge whichever is earlier | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse events and side effects between the two groups during hospital stayTimepoint: Adverse events and side effects between the two groups during hospital stay;All cause death/ neurodevelopmental delay at 18 months of age Timepoint: All cause death/ neurodevelopmental delay at 18 months of age | — |
Countries
India
Contacts
Public Contactshruthi k bharadwaj
JIPMER
Outcome results
None listed