Health Condition 1: null- Hyperinsulinemic hypoglycemia, small for date neonates
Conditions
Interventions
Intervention1: Intervention - Diazoxide
: 3 mg/ kg/ dose
three times a day
per oral till baby becomes euglycemic for atleast 72 hour duration and attains full enteral feeds (150ml/kg/day)
Control Inte
Sponsors
Post graduate institute of medical education and research
Eligibility
Inclusion criteria
Inclusion criteria: 1. Inborn babies born >=32 weeks 2. Days of life 3. Small for gestational age, defined as weight less than 10th percentile for that gestation as per Lubchencoâ??s chart 4. Presence of hyperinsulinemic hypoglycemia (RBS value of
Exclusion criteria
Exclusion criteria: 1. Severe perinatal asphyxia (5 minutes APGAR score 2. Necrotising enterocolitis or any condition where oral feeds are contraindicated at enrolment 3. Major congenital malformations 4.Hypoglycemia attributed to systemic inflammatory response syndrome 5. Congestive cardiac failure 6. Suspecetd endocrine diseases like, congenital adrenal hyperplasia, congenital hypothyroidism 7. Suspected cases of inborn errors of metabolism
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The time taken for hypoglycemia controlTimepoint: sugar values in euglycemic range for a period of 72 consecutive hours after starting the therapy | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Total duration of intravenous glucose infusion 2. Time to attain full feeds @150 ml/kg/day (in days) or 100 % of total daily volume intake as oral feeds 3. Time to attain euglycemia (in days) (BS 50 mg% for 24 hrs) 4. Incidence of sepsis (both definite and suspected) 5. Mortality Timepoint: Till discharge from hospital or death | — |
Countries
India
Contacts
Public ContactDrBinesh B
PGIMER
Outcome results
None listed