Health Condition 1: null- Respiratory distress
Conditions
Interventions
Intervention1: Initial CPAP pressure - 7 cm of water: We will initiate CPAP at 7 cm of water to neonates with respiratory distress and then adjust according to clinical condition
Control Intervention1
Sponsors
Fernandez Hospital
Eligibility
Inclusion criteria
Inclusion criteria: Neonates fulfilling ALL of these criteria would be eligible for enrolment 1.Born at gestation 2.Having respiratory distress at less than 24 hours of age and requiring CPAP {defined as having tachypnea (respiratory rate >60) and/ or Silverman Anderson Score >=3}.
Exclusion criteria
Exclusion criteria: Neonates with any of the following 1. Major congenital malformation 2. Contra-indication for CPAP ( Poor respiratory drive, choanal atresia, cleft palate) 3. Severe metabolic acidosis 4. On Dopamine or dobutamine > 10 micrograma/kg/min 5. Active seizures 6. APGAR 7. Severe respiratory distress at onset requiring mechanical ventilation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| CPAP failure (need of mechanical ventilation in the first week of life).Timepoint: CPAP failure (need of mechanical ventilation in the first week of life). | — |
Secondary
| Measure | Time frame |
|---|---|
| Bronchopulmonary dysplasia (BPD) (oxygen dependency at 28 days)Timepoint: 28 days of life;Chronic lung disease (CLD) (oxygen dependency at 36 weeks postmenstrual age)Timepoint: at 36 weeks postmenstrual age;Duration of oxygen requirement (total duration of all types of oxygen therapy)Timepoint: Till discharge;Gastric perforationTimepoint: Till discharge;Hospital stay (time period from admission till discharge)Timepoint: Till discharge;Incidence of airleak syndrome Timepoint: till the neonate on CPAP;Intraventricular hemorrhage (IVH)Timepoint: Till discharge;Late onset sepsis (proven or suspected)Timepoint: Till discharge;Local injury(nasal injury, bleeding)Timepoint: till the neonate on CPAP;Necrotising enterocolitis (NEC)Timepoint: Till discharge;Need of dopamine or dobutamine more than 10 microgram per minuteTimepoint: till the neonate on CPAP;Need of volume expandersTimepoint: till the neonate on CPAP;Nursery stay(time period in NICU)Timepoint: Till transfer to room or discharge;Patent Ductus Arteriosus(PDA)Timepoint: Till discharge;Periventricular leukomalacia(PVL)Timepoint: Till discharge;Retinopathy of prematurity (ROP)Timepoint: Till discharge;Time taken to reach full feeds (150 ml per kg per day)Timepoint: till the time to reach full feeds;Time taken to start feedsTimepoint: Till discharge;Total duration of respiratory supportTimepoint: Till discharge | — |
Countries
India
Contacts
Public ContactDr Srinivas Murki
Fernandez Hospital
Outcome results
None listed