Health Condition 1: null- patients with inoperable oesophageal carcinoma (ECOG 1-3)
Conditions
Interventions
Intervention1: Radiotherapy and chemotherapy: Radiotherapy dose of 30 GY along with oral capecitabine for 12 days and cisplatin infusion on Day 1 to 3 and Day 10 to 12 will be given after endoscopi
Sponsors
None listed
Eligibility
Inclusion criteria
Inclusion criteria: i) Oesophageal and gastro oesophageal junction cancer patients with • Locally advanced unresectable cancer such as invasion of tracheobronchial tree, aorta, pulmonary vascular structures. • Metastatic disease. • Comorbid conditions or general health status precluding a major surgical procedure with grade III and IV dysphagia. • Performance status of 0-2 on the Eastern Cooperative Oncology Group (ECOG) scale ii) Vocal cord palsy. iii) Dysphagia grades 3 and 4. iv) Biopsy proven carcinoma - both squamous cell and adenocarcinoma
Exclusion criteria
Exclusion criteria: i) Carcinoma of cervical oesophagus ii) Patients who had already received prior radiation or chemo radiotherapy or any other modality of treatment. iii) Patients unstable for endoscopic procedure and for radiotherapy/chemoradiotherapy due to severe co-morbid illness such as congestive heart failure, severe hepatic and renal failure.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| i) To compare relief of dysphagia and quality of life (QOL) in patients with inoperable oesophageal cancer treated with stenting followed by radiotherapy versus those treated with stenting followed by chemoradiotherapyTimepoint: to measure QOL every two months till death | — |
Secondary
| Measure | Time frame |
|---|---|
| i) To assess overall survival (OS) benefit of chemoradiotherapy following stenting versus radiotherapy following stenting in these patients. ii) To assess treatment related complications between the two treated groups Timepoint: to find the overall survival benfit and treatment complications at the end of the study | — |
Countries
India
Contacts
Public ContactDr v arun kumar
AIIMS
Outcome results
None listed