Health Condition 1: null- All patients of Ca Esophagus or GE Junction planned for NACT in thoracic joint clinic will be included if they are fit to receive platinum based chemotherapy
Conditions
Interventions
Intervention1: 5-Fluorouracil with Platinum: 5 FU 1000mg/m2 day 1- day 4 with cisplatin 75 mg/m2 day 1 OR carboplatin AUC 6 every 3 weeks for 3 cycles. Since both these regimens are established standa
Sponsors
Tata Memorial Hospital
Eligibility
Inclusion criteria
Inclusion criteria: Inclusion Criteria: 1. Histologic confirmation of pathology: Squamous cell or adenocarcinoma of ca esophagus or GE junction. 2. Age 18 years or older 3. Eastern Cooperative Oncology Group performance status of 0 to 2 4. Adequate bone marrow, hepatic, renal, and pulmonary function 5. Willingness to provide written informed consent.
Exclusion criteria
Exclusion criteria: Exclusion criteria shall be: 1. Prior therapy for carcinoma esophagus or GE junction 2. Evidence of distant metastases 3. Received any of the investigational product in the last 30 days 4. Patients who were pregnant or lactating 5. Patients with uncontrolled or severe cardiovascular disease 6. Pre-existing neurotoxicity greater than National Cancer Instituteâ??Common Toxicity Criteria (NCI-CTC) grade 2
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary- Efficacy of these two regimens (TRG Post Chemotherapy) Timepoint: 3 years | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary - Safety of these two regimens QOL in these two regimens Hospital admission required after chemotherapy administration R0 resection rate Progression free survival Overall Survival Timepoint: 3 years | — |
Countries
India
Contacts
Public ContactDr Vibhor Sharma
Tata Memorial Hospital
Outcome results
None listed