A clinical trial to study the effects of Simvastatin on reduction in inflammation and improvement in functional status of patients with knee joint pains.

Anti-inflammatory effect of Simvastatin and its impact on Western Ontario and McMaster Universities (WOMAC) scores in patients with mild to moderate knee osteoarthritis.

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2014/03/004469

Enrollment

180

Registered

2014-03-12

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Mild to moderate osteoarthritis

Interventions

Intervention1: Intervention - Tablet Simvastatin 20 mg once daily per oralfor 12 weeks. : All the enrolled patients will receive the standard non pharmacological and pharmacological therapy according

Eligibility

Inclusion criteria

Inclusion criteria: Patients with American society of anesthesiologist (ASA) Iâ??II ,mild to moderate knee OA based on clinical history of knee pain with grade 1-3 of Kellgren-Lawrence radiological grading for OA and having at least one of the following: Patient age 50-80 years Morning stiffness lasting 30 minutes or less Crepitus on motion Patients receiving standard non pharmacological and medical treatment of OA since three months without any significant alterations.

Exclusion criteria

Exclusion criteria: Patient refusal A body mass index (BMI) >40 kg/m2. Patients who are receiving drugs that might interact with statins. Ciclosporins , Fibrates, Azol anti-fungals, Macrolide antibiotics, Antiarrhthymics(Verapamil, Amiodarone), Nefazodone ,Arotease inhibitors, anticoagulants ,tramadol and paracetamol combinations. OA due to trauma, referred pain syndromes, septic/crystal arthritis and hemarthrosis and soft tissue conditions. Patients with diabetes, serious medical condition, renal and hepatic disease, or deranged function tests. Patients with existing pregnancy or breastfeeding. Patients with Known hypersensitivity to Simvastatin

Design outcomes

Primary

Measure	Time frame
Primary aim of this study will be to evaluate effect of Simvastatin on Western Ontario and McMaster Universities WOMAC score in patients with mild to moderate knee OATimepoint: 03 years	—

Secondary

Measure	Time frame
To study effect of simvastatin on inflammatory markers total consumption of analgesics number of acute pain events range of movements and any adverse events.Timepoint: 03 years	—

Countries

India

Contacts

Public ContactDr Deepak Thapa

Government Medical College and Hospital Chandigarh

dpkthapa@gmail.com9646121524

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026