Health Condition 1: null- Pregnant women with gestational diabetes not controlled with medical nutritional therapy (MNT)
Conditions
Interventions
Intervention1: Metformin: Pregnant women recruited to receive metformin will be started on 500mg,
once a day and this will also be increased in a weekly stepwise manner to a maximum of 2500 mg a day
Sponsors
Christian Medical College and Hospital
Eligibility
Inclusion criteria
Inclusion criteria: Pregnant women from 20-33 weeks Fasting glucose >=99mg% and = 120mg% and
Exclusion criteria
Exclusion criteria: Pre-existing type 1 or 2 diabetes Currently taking metformin for some other indication. Multiple pregnancy. Recognised foetal congenital anomaly. Known abnormal renal or liver function. Hypoxic cardio-respiratory disease. Mal-absorption or some other significant GI disease. Sepsis. Ruptured membranes. Gestational hypertension or pre-eclampsia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The Primary outcome of the study were a composite of salient neonatal outcomes that include: â?¢Macrosomia â?¢Birth weight more than 3700gms â?¢Hypoglycaemia less than 40mg percent â?¢Need for phototherapy â?¢Respiratory distress â?¢Stillbirth or neonatal deaths â?¢Birth trauma Timepoint: 20 percent | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcomes include: â?¢Birth weight â?¢Maternal glycaemic control â?¢Pregnancy induced hypertension â?¢Need for induction of labour â?¢mode of delivery â?¢complications of delivery such as third and fourth degree perineal tears. Timepoint: 30 percent | — |
Countries
India
Contacts
Public ContactJiji Elizabeth Mathews
Christian Medical College and Hospital
Outcome results
None listed