Health Condition 1: null- Luteal Phase Deficiency
Conditions
Interventions
Intervention1: 1. Oral Micronized Natural Progesterone Sustained release or
2. Dydrogesterone: 1. 400 mg- 1 tab at bedtime orally for 4 weeks
2. 10 mg- 1 tab twice daily orally for 4 weeks
Intervent
Sponsors
Sooriya Hospital
Eligibility
Inclusion criteria
Inclusion criteria: • Married females (18 to 33 yrs) with at least Three years history of Infertility • Suspected or documented evidence of Luteal Phase defect with or without history of Recurrent pregnancy loss, OR • Unexplained infertility
Exclusion criteria
Exclusion criteria: • History of Progesterone (Natural or synthetic) use in the past three months • History of tubal insufficiency or obstruction including Endometriosis or Polycystic Ovarian Syndrome • History of psychoactive disease or on antidepressants • AST and / or ALT more than 2.5 x ULN (active liver disease) • Serum creatinine more than 1.5 mg/dl (active renal disease) • Women with Uncontrolled hypertension, hypercholesterolemia or diabetes • Women with history of smoking, myocardial infarction, stroke, cardiovascular/circulatory or clotting disorders • Women on oral anticoagulants or prolonged use of high doses of NSAIDs • Hypersensitivity to Natural micronized progesterone or Dydrogesterone
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Percentage patients with successful pregnancy confirmed by Urinary HCGTimepoint: 4 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| Percentage patients with Sr. Progesterone levels more than 10 ng/mlTimepoint: Day 23 of the cycle | — |
Countries
India
Contacts
Public ContactDr Krishnaprasad
SOORIYA Hospital
Outcome results
None listed