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Treatment of gum disease by periodontal surgery

Autologous platelet rich fibrin with guided tissue regeneration membrane in the treatment of intra-bony defects in chronic periodontitis patients- A randomized, double blind, controlled clinical trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2014/02/004405
Enrollment
32
Registered
2014-02-14
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Chronic periodontitis patients

Interventions

Intervention1: Platelet rich fibrin with Guided tissue regeneration barrier membrane: Autologous PRF is procured from patients whole blood of 5ml and subjecting it to centrifugation at 3000 rpm for 10

Sponsors

Saveetha Dental College
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Subjects within the age group of 30 years to 50 years. 2. Subjects with Chronic Periodontitis ( On basis of 1999 consensus classification of periodontal disease) 3. Presence of inter-proximal IBDs >= 2mm deep (distance between alveolar crest and base of the defect on IOPA) 4. Presence of inter-proximal probing depth(PD) >= 5mm following phase I therapy (SRP) 5. Systemically healthy subjects with no debilitating conditions.

Exclusion criteria

Exclusion criteria: 1. Subjects with history of periodontal surgical treatment within the last six months. 2. Former / current smokers. 3. Immuno-comprimised subjects. 4. Subjects having unacceptable oral hygiene (PI >1.5) after re-evaluation of phase I therapy. 5. Pregnant and lactating mothers. 6. Subjects on antibiotic therapy within the last six months. 7. Subjects on treatment with steroids. 8. Subjects with non-vital teeth, teeth with furcation defects or teeth with mobility >= Grade II and teeth with endodontic-periodontal involvement. 9. Acute abscesses of periodontium.

Design outcomes

Primary

MeasureTime frame
1. Plaque Index(PI)- (Silness and Loe index) 2. Sulcus Bleeding Index(m SBI) 3. Gingival Marginal Level (GML) 4. Probing Pocket Depth (PPD) 5. Clinical attachment loss (CAL 6. Defect depth Timepoint: All the outcomes to be assessed at the end of 3 months, 6 months and 9 months post-operatively—

Secondary

MeasureTime frame
Defect depthTimepoint: Baseline and 9 months—

Countries

India

Contacts

Public ContactSaurav

Saveetha Dental College

profndj@yahoo.com9840104551

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026