Comparison of two doses of a drug named Clonidine which is added to an injection of other drug used to block nerves of upper limb for surgery on bones

Clinical evaluation of clonidine as an adjuvant to Bupivacaine in Supraclavicular brachial plexus block for upper limb orthopaedic surgery - Effect of two different doses of clonidine

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2014/02/004398

Enrollment

150

Registered

2014-02-11

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- any orthopaedic surgery for upper limbs

Interventions

Intervention1: sensorcaine 0.5% 25cc and clonidine 60 and 90 microgram: evaluation of clonidine which is an alpha 2 adrenergic agonist in two separate doses of 60 and 90 micrograms used as an adjuvan

Eligibility

Inclusion criteria

Inclusion criteria: patients posted for upper limb orthopaedic surgery patients aged between 18 to 40 years patients of either sex male or female patients of asa physical status I and II

Exclusion criteria

Exclusion criteria: patients refusing consent contraindications to regional anaesthesia diabetes mellitus previous nerve injury history of drug dependence or abuse history of drug allergy patients taking analgesics and sedatives patients on anticoagulants history of bleeding disorders any major systemic illness antenatal females psychiatric illness uncooperative patients inadequate effect requiring supplementation

Design outcomes

Primary

Measure	Time frame
sensory characteristics of block onset peak duration post operative analgesia motor characteristics of block onset peak duration effect on haemodynamic variables like pulse systolic diastolic and mean blood pressure oxygen saturation sedation score Timepoint: all parameters to be recorded at 1,3,5,10,15,30 minutes and then at 15 minutes interval till the completion of surgery	—

Secondary

Measure	Time frame
complications to be noted like nerve injury bradycardia and hypotension postoperatively and follow up of patients thereafter in case of nerve injuriesTimepoint: post operatively all parameters to be recorded at half hourly intervals till the offset of sensory and motor blockade and then at 4 hourly intervals for 24 hours follow up of patients in opd every 6 months for initial first year and then yearly if they develop nerve injury	—

Measure

Time frame

complications to be noted like nerve injury bradycardia and hypotension postoperatively and follow up of patients thereafter in case of nerve injuriesTimepoint: post operatively all parameters to be recorded at half hourly intervals till the offset of sensory and motor blockade and then at 4 hourly intervals for 24 hours follow up of patients in opd every 6 months for initial first year and then yearly if they develop nerve injury

—

Countries

India

Contacts

Public ContactRaman Piplani

Government Medical College, Bhavnagar, Gujarat, India

drtripathi1961@yahoo.co.in09428408718

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026