Study to find out the safety and efficacy of Pralidoxime in the management of patients with acute organophosphorous pesticide poisoning

Pralidoxime in acute organophosphorous poisioning - A randomized trial

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2014/02/004392

Enrollment

150

Registered

2014-02-10

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Acute organophosphorous poisoning

Interventions

Intervention1: Pralidoxime plus atropine: Intravenous pralidoxime 2 grams loading dose followed by 1 grams every 6th hourly for 3 to 5 days in addition to atropine and other supportive measures as in

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patients with organophosphate poisoning 2.Age > 18yrs 3.Presenting within 12 Hours of ingestion

Exclusion criteria

Exclusion criteria: 1.Patients with mixed compound poisioning 2.Patients with carbamate poisioning 3.Intubated and mechanically ventilated before presentation 4.Received more than 1 dose of pralidoxime before randomization

Design outcomes

Primary

Measure	Time frame
Need for Mechanical ventilation and/or deathTimepoint: Need for Mechanical ventilation and/or death	—

Secondary

Measure	Time frame
Cumulative atropine requiredTimepoint: Until discharge or death;Duration of mechanical ventilationTimepoint: Until discharge or death	—

Countries

India

Contacts

Public ContactChanaveerappa Bammigatti

JIPMER

versatilevijaym@gmail.com

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026