Role of probiotics in prevention of hospital acquired infections in patients on ventilation by machine

Role of probiotic prophylaxis against nosocomial infections in patients on mechanical ventilation-an open labeled randomised controlled trial

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2014/02/004381

Enrollment

150

Registered

2014-02-05

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Nosocomial infections

Interventions

Intervention1: probiotics: probiotics 1 tab(2million CFU lactobacillus and 1 million CFU bifidobacterium)twice a day for 7days Control Intervention1: No treatment: no treatment

Eligibility

Inclusion criteria

Inclusion criteria: Patients who are ventilated for more than 24 hrs

Exclusion criteria

Exclusion criteria: Known Immunodeficiency( HIV patients,patients on steroids, immunosuppressives) 2) Paralytic ileus 3) Gastric bleeds requiring fluid resuscitation or blood transfusion 4) Patients included in other study

Design outcomes

Primary

Measure	Time frame
Incidence of Ventilator Associated Pneumonia(VAP)Timepoint: during ICU stay	—

Secondary

Measure	Time frame
Duration of ICU stayTimepoint: ICU stay;incidence of diarrhoeaTimepoint: during ICU stay;Incidence of nosocomial sepsisTimepoint: during ICU stay;MortalityTimepoint: during ICU stay	—

Countries

India

Contacts

Public ContactDrNiranjan Biswal

JIPMER

banu.13@gmail.com9994744311

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026