Health Condition 1: null- Patients with an established diagnosis of liver cirrhosis without any overt symptoms at time of testing with Grade 0 of West Haven criteria
Conditions
Interventions
None listed
Sponsors
Abbott India Limited
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patients of either sex, 18-65 years of age, who have attended school at least till the 5th Class/Standard, having an established diagnosis of liver cirrhosis without any overt symptoms at time of testing with Grade 0 of West Haven criteria. 2. Patients willing to undergo the neuropsychological (NP) tests and to complete the SF-36 questionnaire for the estimation of HRQOL. 3. Patients willing to provide written authorization to provide data for the study.
Exclusion criteria
Exclusion criteria: 1. History of recent alcohol intake ( 12 weeks)/substance abuse , or gastrointestinal bleeding ( 4 weeks), serious infection, use of drugs affecting psychometric performances ( 4 weeks). 2. Severe medical problems that could influence quality-of-life measurement 3. Inability to perform neuropsychometric tests and to complete the SF-36 questionnaire. 4. Patients with neuropsychiatric diseases like stroke, epilepsy, dementia, parkinsonism etc. 5. Hepatocellular carcinoma
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Prevalence (%) of MHE among cirrhotic patientsTimepoint: Baseline (single visit) | — |
Secondary
| Measure | Time frame |
|---|---|
| Assessment of HRQOL in MHE patients using SF-36 questionnaireTimepoint: Baseline (single visit);Demographic characteristics of the patientsTimepoint: Baseline (single visit);Detailed history on smoking and past history of alcohol consumptionTimepoint: Baseline (single visit);Etiology and co-morbid conditions associated with cirrhosisTimepoint: Baseline (single visit);Laboratory and other investigations like radiology or endoscopy findings, if availableTimepoint: Baseline (single visit);Pattern of drug prescription after diagnosis of MHE in treatment of naïve and those on therapyTimepoint: Baseline (single visit);Pattern of drug prescription before diagnosis of MHE in treatment of naïve patients and those on therapyTimepoint: Baseline (single visit);Subgroup analysis using MMSE score, Child Pugh Score and MELDTimepoint: Baseline (single visit) | — |
Countries
India
Contacts
Public ContactDr Ravi Shankar
Postgraduate Institute of Medical Education & Research
Outcome results
None listed