Health Condition 1: null- MIGRAINE
Conditions
Interventions
Intervention1: AMITRIPTYLINE HYDROCHLORIDE 5 MILLIGRAM: used in the dosage of 5 milligram once daily per orally(bed-time)for three months
Control Intervention1: AMITRIPTYLINE HYDROCHLORIDE 10 MILLIGRA
Sponsors
Sree Mookambika Institute of Medical Sciences
Eligibility
Inclusion criteria
Inclusion criteria: diagnosis of Migraine either with or without aura as per International Headache Society (2013, 3rd edition) definition of Migraine, with a.more than two attacks of headache per month b.prolonged duration of headache (lasting for more than two hours) c.severe attacks of headache with substantial disability d.headache refractory to abortive drug therapy or in whom abortive drug therapy is intolerable, contraindicated or overused (more than twice a week)
Exclusion criteria
Exclusion criteria: a.Patients with other known causes of headache in addition to migraine b.Patients with known contraindications to use of Amitriptyline c.Patients with known hypersensitivity to Amitriptyline
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1.Headache scoring(0-10 point numeric pain rating scale) 2.Physician Global Assessment, Response to Treatment scoringTimepoint: at the end of one, two and three months of recruitment | — |
Secondary
| Measure | Time frame |
|---|---|
| occurence of intolerable side effects- mental confusion, palpitations, hypotension, sedation, constipation, urinary retentionTimepoint: one, two and three months | — |
Countries
India
Contacts
Public ContactSRINISH G
SREE MOOKAMBIKA INSTITUTE OF MEDICAL SCIENCES
Outcome results
None listed