Health Condition 1: null- Multidrug Resistant Tuberculosis
Conditions
Interventions
Intervention1: Injection kanamycin (intramuscular) intermittent: Intermittent Kanamycin is given as intramuscular injection thrice weekly along with oral anti-TB drugs for 6 months
Control Interventio
Sponsors
United State Agency for International Development
Eligibility
Inclusion criteria
Inclusion criteria: A patient whose TB is due to bacilli resistant to at least isoniazid and rifampicin with or without resistance to other drugs will be eligible for the study. At least one sputum smear examined within 10 days of starting treatment should be positive for AFB.
Exclusion criteria
Exclusion criteria: Patients under 15 years of age Pregnant women Having a current major psychiatric illness Having had over one month treatment with any second line anti-TB drugs. HIV positive cases A patient with concurrent illness such as epilepsy, renal or hepatic problems. Too sick for ambulatory treatment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| sputum smear and culture conversion at 3 months and 6 months of treatmentTimepoint: sputum smear and culture conversion at 3 months and 6 months of treatment | — |
Secondary
| Measure | Time frame |
|---|---|
| Favourable bacteriological response at the end of treatment. Adverse reactions to anti-TB drugs Timepoint: at 24 months of treatment | — |
Countries
India
Contacts
Public ContactDr Soumya Swaminathan
National Institute for Research in Tuberculosis
Outcome results
None listed